• The present in vitro pharmacological experiments revealed th

  2024-03-07

  

  The present in vitro pharmacological experiments revealed that the cholinergic up-regulation of VEGF expression in neurons and astrocytes was mainly mediated by nicotinic AChR and muscarinic AChR, respectively. In addition, neuronal VEGF expression was elevated by endogenous ACh in a manner that was

• The present study indicates elevated ATX activity as

  2024-03-07

  

  The present study indicates elevated ATX activity as a highly sensitive and specific biomarker to differentiate ICP from other pregnancy-related liver disorders or pruritic dermatoses. In GS-4997 to the current gold standard for diagnosis, total fasting serum bile salt levels, ATX appeared as a ver

• Elevated expression of Aurora A

  2024-03-07

  

  Elevated expression of Aurora-A and -B frequently detected in a wide variety of human cancers strongly indicate that high expression of these kinases play roles in the development of cancer associated phenotypes. While Aurora-A has been shown to function as an oncogene when over expressed in mammali

• nor-Binaltorphimine dihydrochloride The amino hydroxy methyl

  2024-03-06

  

  The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic nor-Binaltorphimine dihydrochloride (AMPA) receptor is also enriched in postsynaptic striatal neurons (Bernard et al., 1997, Kondo et al., 2000, Reimers et al., 2011). Its activity is subjected to the regulation by a mechanism involving phosphoryl

• br Introduction Endothelial progenitor cells EPCs present a

  2024-03-06

  

  Introduction Endothelial progenitor cells (EPCs) present a class of blood cells with an ability to form new blood vessels relying on pre-existing vessels, which contribute to postnatal angiogenesis [1], [2]. A wide range of studies have demonstrated that EPCs play a critical role in angiogenesis

• br Metabolic effects of apelin in obesity and

  2024-03-06

  

  Metabolic effects of apelin in obesity and type 2 diabetes Mice fed a high fat diet (HFD) for several weeks become obese, hyperglycemic, hyperinsulinemic and insulin resistant. Acute apelin treatment by intravenous injection or by infusion during a hyperinsulinemic–euglycemic clamp in obese and i

• For all three fluorescent dyes used the double

  2024-03-06

  

  For all three fluorescent dyes used, the double-labeled UQ-bodies showed higher antigen responses. A plausible mechanism for the higher quenching observed for the double-labeled UQ-bodies is the dye-dye quenching due to H-dimer formation [19] between the two dyes introduced into the Fd and L chains.

• br Results and discussion br Conclusion The

  2024-03-06

  

  Results and discussion Conclusion The tyrosine kinase ALK represents one of the most successful molecular targets for the development of precise medicine to treat stratified subgroups of cancer patients. Three generations of ALK inhibitors have been awarded the FDA's approval or are being exte

• Introduction Pyometra is relatively common in intact bitches

  2024-03-06

  

  Introduction Pyometra is relatively common in intact bitches and its diagnosis is aided by ultrasonography (Bigliardi et al., 2004), along with measurement of acute phase proteins and leucocyte (white blood cell, WBC) counts; assessment of these parameters during recovery may be helpful for monitor

• In this study we obtained the absorbance and photoluminescen

  2024-03-06

  

  In this study, we obtained the absorbance and photoluminescence (PL) of Coumarin polymerized with various types of actin-binding proteins in order to probe the actin structures in situ without labeling. Both optical measurements have been useful in examining biomaterials such as DNA and proteins wi

• We have previously reported alterations of the thymus in ACh

  2024-03-06

  

  We have previously reported alterations of the thymus in AChR-MG patients, especially in their germinal center N-(p-amylcinnamoyl) receptor (defined as CD19+CD38+ cells by flow cytometric analysis). First, we found that, in MG thymi, this subset failed to show the normal down-regulation of Bcl-2, s

• br Results br Discussion Dopamine

  2024-03-05

  

  Results Discussion Dopamine regulates behavioral responses to nicotine in Drosophila (Bainton et al., 2000), but neurochemical measurements of dopamine after nicotine stimulation had not been made. Here, we demonstrate for the first time that the stimulation of nAChRs causes dopamine release i

• The lack of benefit in terms of

  2024-02-23

  

  The lack of benefit in terms of overall survival for antiangiogenic treatment was similar when antiangiogenic drug was used both as first and second-line therapy, and both in association with cytotoxic treatment or alone. Noteworthy, a trend for an inferior outcome was observed in the group of patie

• br Special report Financial and personal benefits of early d

  2024-02-23

  

  Special report – Financial and personal benefits of early diagnosis Acknowledgments The Alzheimer’s Association acknowledges the contributions of Joseph Gaugler, Ph.D., Bryan James, Ph.D., Tricia Johnson, Ph.D., Allison Marin, Ph.D., and Jennifer Weuve, M.P.H., Sc.D., in the preparation of 201

• It was also shown that of crizotinib resistance mechanisms c

  2024-02-23

  

  It was also shown that 15% of crizotinib resistance mechanisms can be due to an amplification of ALK gene while 30% are caused by a variety of secondary mutations (S1206Y, G1202R, L1196M, C1156Y, G1269A, L1152R, F1174L and 1151Tins) in ALK tyrosine kinase. These mutations can modify the conformation

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