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br Antioxidant polymers conjugates Natural antioxidants are
2023-10-16
Antioxidant-polymers conjugates Natural antioxidants are usually used as a substitute for synthetics but some degradation phenomena could influence their applications. For example, ascorbic most as a natural antioxidant undergoes yellowish coloration as a result of oxidation [29]. Sing and Kapla
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The reception of antiangiogenic treatment in neuro oncology
2023-10-16
The reception of antiangiogenic treatment in neuro-oncology has yet to achieve the wide success rapidly accomplished for other malignancies. In 1984, mutated receptor tyrosine kinase became a culprit for aberrant tumorigenesis signal, providing a target for monoclonal 5 ala (mAbs) and small-molecule
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br Identification of the croaker mAR cDNA
2023-10-16
Identification of the croaker mAR cDNA Testosterone (T) was observed to alter steroidogenesis through a nongenomic mechanism (not blocked by the transcription inhibitor, actinomycin D) in Atlantic croaker ovarian tissues (Braun and Thomas, 2003). This action of T was mimicked by T conjugated to B
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Similar studies in Swedish Mutation of APP
2023-10-16
Similar studies in Swedish Mutation of APP AD transgenic mice revealed reduced dynamin 1, AP180, and synaptophysin expression in the hippocampus, particularly prominent in the CA1 and CA4 subfields [19]. These findings imply that Aβ can act not only as a modulator of exocytosis but is a potent regul
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Compounds and with potent ALR
2023-10-16
Compounds , and with potent ALR2 inhibitory activity were also tested for their inhibition ability against ALR1, as shown in . They all showed low activity with inhibition percentages no more than 45% at the concentration of 10μM, demonstrating good selectivity for ALR2. To evaluate the antioxidant
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br ABCA is a sterol responsive gene The first
2023-10-16
ABCA2 is a sterol-responsive gene The first evidence to demonstrate that ABCA2 expression responded to sterol loading was provided in an experiment involving monocyte to macrophage differentiation in vitro. Upon sterol loading with enzymatically degraded LDL (eLDL), ABCA2 expression increased onl
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Introduction Glaucoma consists of a group of eye
2023-10-16
Introduction Glaucoma consists of a group of eye diseases showing a broad spectrum of clinical presentation and unknown aetiologies, that lead to a permanent loss of visual function due to the death of retinal ganglion multidrug resistance transporter and damage of the optical nerve. It is well acc
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br Conclusions Triptans are HT B D F receptors
2023-10-16
Conclusions Triptans are 5-HT1B/1D/(1F) receptors agonists and are considered as the gold standard for acute migraine treatment that have been proven effective. Unfortunately, they are contraindicated in patients with cardiovascular diseases due to their vasoconstrictor (side) effects (MaassenVan
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Specifically equity injections in a multinational affiliate
2023-10-16
Specifically, equity injections in a multinational affiliate X located in an ACE country can be passed on as lending to another group member Y located in a different country with a high corporate income tax rate. For the group member Y, the interest on the loans is tax deductible, and at the same ti
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br Conclusions Triptans are HT B D F receptors
2023-10-16
Conclusions Triptans are 5-HT1B/1D/(1F) receptors agonists and are considered as the gold standard for acute migraine treatment that have been proven effective. Unfortunately, they are contraindicated in patients with cardiovascular diseases due to their vasoconstrictor (side) effects (MaassenVan
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br Cytochrome b br Cytochrome P hydroxylase
2023-10-16
Cytochrome b5 Cytochrome P450 17α-hydroxylase/17,20-lyase (P450 17A1) A number of P450s involved in steroid biosynthesis are multifunctional as they carry out two or more sequential hydroxylation reactions on the same substrate(s). P450 17A1 is a dual function endoplasmic reticulum enzyme enco
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Congruously our findings of voltage electrode clamping assay
2023-10-16
Congruously, our findings of voltage-electrode-clamping assays indicate that hipN851K mutation mediates partial loss of Na+/K+-ATPase pump currents, also confirming our thesis that hipN851K mutation acts as a hypomorph. As demonstrated here by our external electrical stimulation studies and ECG reco
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In this study we found that ACL silencing is
2023-10-16
In this study, we found that ACL silencing is sufficient to impair myoblast differentiation and that this effect is accompanied by a decrease in MYOD early in the myogenic process and by a subsequent decline in fast MyHC protein Octreotide acetate at a later stage of differentiation (Figure 4J). Fu
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Recent studies revealed that certain plant derived
2023-10-13
Recent studies revealed that certain plant-derived compounds can also interfere with AR function. One way of such an interference is by modulating its expression levels. This is the case for the two flavonoids quercetin and luteolin that have been reported to repress the function of AR by inhibiting
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Our conclusion was confirmed by two experiments The addition
2023-10-13
Our conclusion was confirmed by two experiments. The addition of aminopeptidase-specific inhibitors at high concentrations allowed us to exclude the possibility of substrate hydrolysis by other proteases present in the samples, for example, endoproteases. After the application of inhibitors, we were
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