• br Methods and materials br Results br Discussion GPCR

  2023-11-01

  

  Methods and materials Results Discussion GPCR regulation in response to agonist stimulation is common to nearly all GPCRs and is essential in physiological systems to limit persistent signalling. In this study we have investigated the [Pyr1]apelin-13-induced trafficking and desensitization

• Although the earlier studies focused on the antioxidant

  2023-11-01

  

  Although the earlier studies focused on the antioxidant capacity of tocopherols, ascorbic ibuprofen msds and carotenoids, then it was noticed that phenolic compounds were more powerful than others (Rice-Evans, Miller, & Paganga, 1996). Phenolic compounds, the most numerous and ubiquitous groups of

• It has been proposed that a PrP pathogenic mechanism is

  2023-11-01

  

  It has been proposed that a PrP pathogenic mechanism is a toxic gain of function secondary to the misfolding of mutated PrP. However, such a mechanism might not apply to all mutant PrP species, since some mutations had little effect on the stability and folding kinetics of PrP (Swietnicki et al., 19

• br Introduction Androgens have been shown

  2023-11-01

  

  Introduction Androgens have been shown to regulate several neural functions ranging from reproduction to mood and cognitive abilities. This property starts as early as the perinatal period, which is characterized by prenatal and postnatal surges of gonadal testosterone, and continues through pube

• br Author Contributions br Acknowledgments br Introduction C

  2023-10-31

  

  Author Contributions Acknowledgments Introduction Cerebral ischemia-reperfusion (I/R) injury is a pathological phenomenon that occurs after restoration of blood supply to 82 7 tissues subsequent to ischemia or hypoxia (Carden and Granger, 2000). It typically occurs after therapeutic thromb

• br Introduction Alzheimer s disease

  2023-10-31

  

  Introduction Alzheimer's disease (AD) is a neurodegenerative disorder and the leading cause of dementia. It is characterized by progressive and irreversible damage to different LY3009120 australia areas, resulting in cognitive impairment and behavioral changes (O'Neill, 2013, De Strooper and Kar

• br Materials and methods br Results br Discussion

  2023-10-31

  

  Materials and methods Results Discussion Knowledge of the molecular basis of an inherited genetic disease is crucial for understanding the disease pathology and, ultimately, for therapeutic design. Several recent reports have stressed the need for physical characterization of disease-associ

• Analyses of brain CSCs isolated from pediatric and six

  2023-10-31

  

  Analyses of HBC CSCs isolated from 24 pediatric and six adult brain tumors detected ALDH levels proportional to tumor type and aggressiveness. ALDH-expressing cells (ALDH+) formed spheroids while ALDH1 pharmacological inhibition by a combination of DEAB and RA decreased significantly sphere number

• br Experimental procedure br Funding The present study

  2023-10-31

  

  Experimental procedure Funding The present study was supported by the Grant Russian Foundation for basic research (project no. 16-04-01517). Introduction 5-HT, a monoaminergic neurotransmitter, is synthesised from l-tryptophan catalysed by the enzymes tryptophan hydroxylase (Tph) and aroma

• Our results using RT PCR confirm earlier

  2023-10-31

  

  Our results using RT-PCR confirm earlier findings (Wilisch et al., 1999, Bruno et al., 2004) including the presence of both the P3A+ and P3A− isoforms of the α-subunit (Beeson et al., 1990). The lack of detection of the ε-subunit mRNAs in some thymomas, and lack of α-, β-, δ- and γ-subunit mRNAs by

• The ambiguity surrounding the role played

  2023-10-31

  

  The ambiguity surrounding the role played by the 15-LOXs in malignant biological processes stems also from the limitations of current animal models, and especially the usage of its 12/15-LOX murine homolog, which can also catalyze the production of 12-HETE. Indeed, the proinflammatory effect of 12-H

• br Conclusion This is the first report to show that

  2023-10-31

  

  Conclusion This is the first report to show that treatment of lung cancer cell lines, A549 and H1299, with ovatodiolid stimulates intracellular reactive oxygen species generation and induces DNA damage. Subsequently activates ATM/ATR and CHK1/2 signaling pathway, inhibits CDC25C and p21WAF1/CIP1,

• br Introduction O Dowd et al identified a gene very

  2023-10-31

  

  Introduction O’Dowd et al. identified a gene very similar to angiotensin type-1 receptor in 1993 (O’Dowd et al., 1993). The specific selective ligand of this receptor called APJ receptor was determined by Tatemoto et al. in 1998 as apelin (Tatemoto et al., 1998). The high expression of apelin and

• Protein arrays provide a new approach for

  2023-10-31

  

  Protein arrays provide a new approach for the identification of substrates for several protein-modifying enzymes. For example, protein kinase substrate identification, which constitutes an important aspect of pathway mapping because of the prevalence of these substrates in biological pathways. MacBe

• br Conclusions and perspectives In view of

  2023-10-31

  

  Conclusions and perspectives In view of the evidences supporting that HhAntag MAS receptors mediate the effects of AT1 antagonists (Iwai et al., 2012, Ohshima et al., 2014, Pernomian et al., 2015, Schuchard et al., 2015), the prime targets from the perspectives on future directions in the interp

13446 records 250/897 page Previous Next First page 上5页 246247248249250 下5页 Last page