• Regulators of the DDR have therefore become attractive

  2023-08-30

  

  Regulators of the DDR have therefore become attractive targets for cancer therapy primarily through two potential approaches. First, to be used as chemo- or radiosensitisers to increase the effectiveness of standard genotoxic treatments and to help prevent or overcome the development of resistance.

• Somatostatin analogs also bind to somatostatin receptors

  2023-08-30

  

  Somatostatin analogs also bind to somatostatin receptors. It has been reported that octreotide has a high affinity for hSSTR2, moderate affinity for hSSTR3 and hSSTR5, and does not bind to hSSTR1 or hSSTR4 (Ben-Shlomo and Melmed 2008). Compared to octreotide, pasireotide displays 40-, 30-, and 5-fol

• In the pituitary of R quelen mRNA levels of

  2023-08-30

  

  In the pituitary of R. quelen mRNA levels of cyp19a1b were found to be higher in males than females, suggesting a sex-specific function, and perhaps a local action to regulate gonadotropins or other pituitary hormone secretion (Olivereau and Callard, 1985; Zhang et al., 2014). Interestingly, the hig

• br Apelin The APJ receptor ligand apelin firstly

  2023-08-30

  

  Apelin The APJ receptor ligand apelin firstly in 1998 was segregated from bovine stomach tissue. Human preproapelin gene located on chromosome Xq25–26.1. The apelin preproproteins consist of 77 amino chemical d residues that are cleaved into biologically active C-terminal fragments of various siz

• br Introduction Active oxygen radicals

  2023-08-30

  

  Introduction Active oxygen radicals in the human body have a strong effect of inducing lipid peroxidation, which in turn induces oxidative imbalance and causes various diseases. Natural polysaccharides are substances with certain antioxidant activity. They are used as antioxidants and have advant

• br Other Strategies for HIF

  2023-08-30

  

  Other Strategies for HIF-α Inhibition NSC-644221 is another HIF-α inhibitor acting at the translational level, independently of proteasomal degradation and VHL status, and is devoid of DNA damage-inducing properties [70]. NSC-644221 arrests 2595 in G2–M through a cell type-specific Topo-2-depend

• br Experimental section br Introduction NMDA receptor induce

  2023-08-30

  

  Experimental section Introduction NMDA receptor-induced increases in AMPAR trafficking to the synaptic surface mediates changes in synaptic efficacy in a number of Pexidartinib regions (Shi et al., 1999, Sun et al., 2005, Frenkel et al., 2006). While this process has been linked to the regulat

• This suggestion was confirmed by immunohistochemical studies

  2023-08-30

  

  This suggestion was confirmed by immunohistochemical studies in which the immunoreactivity of the enzyme was actually higher at the earlier rather than at the advanced stages of the disease. Importantly, a later study showed that the biochemical signature of 12/15LO enzymatic activation (i.e., 12-HE

• These results validate the docked

  2023-08-30

  

  These results validate the docked pose of the ALR2-3e complex in comparison to the docked complex of the ALR2-4c complex of which the compound docked completely out of the binding pocket of ALR2 (). This concludes to that the removal of the acetic Paprotrain moiety leads to inactive or weakly acti

• Liver plays a pivotal role in

  2023-08-30

  

  Liver plays a pivotal role in metabolism of xenobiotic compounds, such as environmental contaminants and drugs. Some of these compounds generate hepatic damage and impair its function. It was well-known that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) could induce pathological changes in mouse and ra

• Since the introduction of zebrafish

  2023-08-29

  

  Since the introduction of zebrafish into the laboratory, many milestones have been achieved that firmly establish this organism as a prominent genetic model for biology and medicine. Many features make this species an organism of easy maintenance in laboratory which provides advantages to understand

• That disassembling actin filaments transport chromosomes tow

  2023-08-29

  

  That disassembling ic bupropion filaments transport chromosomes towards the spindle in oocytes may be surprising at first sight. On the other hand, it is well established that chromosome movement during anaphase is driven by the depolymerization of microtubules [20]. It will be interesting to inves

• Our results using RT PCR confirm

  2023-08-29

  

  Our results using RT-PCR confirm earlier findings (Wilisch et al., 1999, Bruno et al., 2004) including the presence of both the P3A+ and P3A− isoforms of the α-subunit (Beeson et al., 1990). The lack of detection of the ε-subunit mRNAs in some thymomas, and lack of α-, β-, δ- and γ-subunit mRNAs by

• Another open question is whether GABA and

  2023-08-29

  

  Another open question is whether GABA and ACh are released from the same synaptic vesicles, or even the same presynaptic terminals. Multi-transmitter neurons may either function through co-release, in which multiple neurotransmitters are packaged into the same presynaptic terminal and are therefore

• During the year study period of men

  2023-08-29

  

  During the 4-year study period, 19.9% of men in the dutasteride group developed prostate cancer as compared to 25.1% in the placebo group, which represents an absolute risk BI-7273 receptor of 5.1% for men taking dutasteride (Pe weighed against the prospect of undesirable sexual side effects and de

13446 records 286/897 page Previous Next First page 上5页 286287288289290 下5页 Last page