• To elucidate whether the impact of hypoxia on

  2021-01-07

  

  To elucidate whether the impact of hypoxia on EGFR expression is cell context specific or culturing density dependent, we chose the following cancer 2449 driven by EGFR and evaluated the EGFR expression after hypoxia treatment at different culturing density: a highly aggressive and poorly different

• Ubiquitination can occur on a

  2021-01-07

  

  Ubiquitination can occur on a single (monoubiquitination) or several (multiubiquitination) lysine residues, or the same lysine residue can be subjected to several rounds of Ub conjugation (polyubiquitination). Ub bonds within polyUb chains are formed through 1 of 7 lysine residues in Ub, and the typ

• As before all calculations are based on thermodynamically fi

  2021-01-07

  

  As before  [3], [4], all calculations are based on thermodynamically first- and second-order hydropathic (amino acid) scales  [6], [7], linearly scaled to a common center and a common range for each of the 20 amino acids. These are then converted to a triangular matrix , where is the length of a sli

• As DNA methylation plays a

  2021-01-07

  

  As DNA methylation plays a critical role in organismic development and human diseases, the interest in DNA methyltransferases is constantly increasing. Extensive studies on the repertoires of dnmts genes have indicated increasing dnmts members in eukaryotes (Goll and Bestor, 2005; Ponger and Li, 200

• DGK is highly expressed in skeletal muscle which

  2021-01-07

  

  DGKδ is highly expressed in skeletal muscle [7], which is a primary target of insulin for glucose disposal [14]. Notably, Chibalin et al. reported that DGKδ contributes to hyperglycemia-induced peripheral insulin resistance and that decreased protein levels of DGKδ in skeletal muscle attenuated gluc

• Aspergillus nigerA niger is another filamentous fungus in wh

  2021-01-07

  

  Aspergillus nigerA. niger is another filamentous fungus, in which alternative dehydrogenases have been described. Filamentous fungi are a very important group of microorganisms that are used in industry (O’Donnell et al. 2011). Biotechnological production processes using these organisms are often hi

• p is a tumor suppressor gene that inhibits cyclin

  2021-01-07

  

  p16 is a tumor-suppressor gene that inhibits cyclin-dependent kinase 4 and 6 activities and arrests the BLU 9931 in the G1 phase. Aberrant methylation and mutation of p16/MTS1 in OSCC of patients was found in our previous study. Moreover, the frequency of hypermethylation of p16 from the present st

• Eukaryotic cell cycle machinery is thought to appropriately

  2021-01-07

  

  Eukaryotic cell cycle machinery is thought to appropriately modulate cell proliferation and cell expansion in various developmental stages and environmental conditions. The core feature of cell-cycle control is the fluctuation of CDK activity, which is regulated by three interactive and conserved m

• Palliative surgeries for refractory epilepsy include

  2021-01-07

  

  Palliative surgeries for refractory epilepsy include vagus nerve stimulation and corpus callosotomy. Among 220 individuals with CDD with parent-entered data, 17% had a vagus nerve stimulation implanted and 69% of parents reported reduced seizure frequency. These data are consistent with a case repor

• br Introduction The endeavor to

  2021-01-06

  

  Introduction The endeavor to achieve a successful use of commercial-off-the-shelf (COTS) electronic devices in space is not new and the reasons are well known [1], [2], [3]. More recently, COTS have been widely employed in the manufacturing of low-cost, small satellites, for scientific and even c

• Asteroids can provide an abundant supply of other resources

  2021-01-06

  

  Asteroids can provide an abundant supply of other resources, such as carbon, nitrogen, or calcium compounds, but will only be useful once the space economy is sufficiently developed to provide economically interesting uses for them. Others, such as titanium or aluminium, also exist in asteroids, but

• Two additional hydrogen bonds are formed

  2021-01-06

  

  Two additional hydrogen-bonds are formed by the -substituted methoxy-group with Ser and Asp. Ser exerts the role of a gate keeper in CK1: Entry of the ATP in the binding-site causes a conformational change into the closed form by Ser, which locks the binding-site and prevents ATP-diffusion out of th

• During the past decade it

  2021-01-06

  

  During the past decade, it became increasingly clear that the affinity and efficacy of small agonists acting on the orthosteric binding site of a GPCR can be modulated by ligands that bind to a topographically distinct (allosteric) binding site on the same GPCR molecule 33, 39, 40, 41, 42. This allo

• cAMP mediated signaling pathways are important for

  2021-01-06

  

  cAMP-mediated signaling pathways are important for maintaining metabolic homeostasis, and the effects of the glucagon/catecholamine–cAMP–PKA axis on energy balance have been well documented [20]. For example, ryanodine of the PKA 2β regulatory subunit (RIIβ) in mice leads to increased expression of

• 2-Amino-ATP br Conflict of interest br Acknowledgments

  2021-01-06

  

  Conflict of interest Acknowledgments This work was supported in part by grants from the , Spain (INCITE08PXIB203092PR). VGM was supported by a FPU pre-doctoral scholarship from the , Spain. MLR was supported in part by a crowdfunding campaign (PRECIPITA), coordinated by the Spanish Foundation

13446 records 577/897 page Previous Next First page 上5页 576577578579580 下5页 Last page