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The differences between ground and transition state
2019-09-16
The differences between ground and transition state properties are exemplified by a comparison of our human–yeast results with those of a structural study of possible differences in ubiquitin-Uba-1 binding in yeast (known structure) with human (simulated in [12]). Their discussion focuses on Ubiquit
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Another pathway that requires proper DUB
2019-09-16
Another pathway that requires proper DUB recruitment is the DNA damage response (DDR). After ultraviolet (UV)-induced DNA damage, monoubiquitylated proliferating cell nuclear antigen (PCNA) mediates signaling that leads to repair. The DUB complex USP1/USP1-associated factor 1 (UAF1) deubiquitylates
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br Introduction DNA dependent protein kinase DNA PK
2019-09-16
Introduction DNA-dependent protein kinase (DNA-PK) is a multicomponent serine/threonine protein kinase and considered a member of the phosphatidylinositol (PI) 3-kinase related kinase (PIKK family). This enzyme plays a critical role in the repair of mammalian DNA double strand breaks (DSBs) throu
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br Hypothesis on DDR protective mode of action The documente
2019-09-16
Hypothesis on DDR1 protective mode of action The documented protective role of DDR1 is quite impressive, demonstrated using different preclinical models (immunologic [46,54,58], obstructive [45], and hypertensive [50]) with different intervention paradigms: genetic ablation [45,50,58,72], silenci
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Cys LT have been shown to be critical for
2019-09-16
Cys-LT have been shown to be critical for stimulation of monocytes to produce various proinflammatory factors [32,67]. Fig. 3 shows results obtained with human peripheral monocyte-derived macrophages differentiated for 6 days with 20 ng/ml macrophage colony-stimulating factor (M-CSF) and challenged
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The idea that ASB can drive compartment expansion in the
2019-09-12
The idea that ASB11 can drive compartment expansion in the CNS is further supported by in vitro work in human neuronal precursors. Nerve growth factor (NGF)-induced differentiation of PC12 pheochromocytoma Vanoxerine [11] and RA-induced human pluripotent teratocarcinoma carcinoma (NT2) cells [12] co
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In contrast to SQLE HMGCR could be
2019-09-12
In contrast to SQLE, HMGCR could be efficiently degraded in Medetomidine HCl mass lacking UBE2J2. However, this was not the case in cells devoid of UBE2G2, as these cells were unable to support 25-hydroxycholesterol (25-HC)-stimulated degradation of HMGCR (Fig. 1C). This finding is consistent with
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br Conclusion The role of DNA PK target in
2019-09-12
Conclusion The role of DNA-PK target in DNA DSB repair renders this biotin-LC-LC-tyramide kinase of great medicinal interest in cancer chemotherapy especially the cancer types of linked to DNA defects. Due to the absence of 3D DNA-PK target structure, different ligand-based methods were applied
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Although both DNA DSBs and DNA
2019-09-12
Although both DNA DSBs and DNA-PK activity increase with aging in skeletal muscle (Figure 1), we cannot conclude that aging-associated increase in DNA-PK activity is solely mediated by chromosomal breaks, as DNA-PK is also activated independently of chromosomal breaks by ROS (Li et al., 2014), which
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br Introduction br Sphingolipid metabolism Sphingolipids are
2019-09-12
Introduction Sphingolipid metabolism Sphingolipids, are fundamental constituents of all eukaryotic membranes and their metabolism is carried out by a broad array of anabolic and PNU-120596 clinical with ceramide as their hub (for a review, (Hannun and Obeid, 2018)). Ceramide can be formed by
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Eleutherococcus senticosus Rupt Maxim Maxim is a shrub belon
2019-09-12
Eleutherococcus senticosus (Rupt. & Maxim.) Maxim is a shrub belonging to the Araliaceae, which is commonly distributed in China, Korea, Japan and Russia. It has been traditionally used as folk medicine for the treatment of rheumatism, diabetes, and hepatitis (Nan et al., 2004). Recent phytochemical
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Defensins are one major class of
2019-09-12
Defensins are one major class of antimicrobial, cationic peptides that are released from Ginsenoside Rd and and imbedded in the mucus layer on mucosal surfaces [45]. They can be categorized into two major families; α- and β-defensins. In humans there are two α-defensin members, defensin 5 (HD5) and
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CPH models reported usually as lists of risk factors
2019-09-12
CPH models, reported usually as lists of risk factors along with their parameters, are prevalent in medical literature. One such model is the CPH model created for the purpose of predicting the probability of one year survival of patients suffering from Pulmonary Arterial Hypertension [5]. The model
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br Introduction Benzanthrone BNZ is a dye intermediate used
2019-09-12
Introduction Benzanthrone (BNZ) is a dye intermediate used in the synthesis of number of polycyclic vat and disperse dyes. It has been detected as an environmental pollutant in urban ambient air particulates, originating from furnace effluents, municipal refuge, wood and coal combustion and autom
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br Dienogest DNG Dienogest is a nortestosterone derivative w
2019-09-12
Dienogest (DNG) Dienogest is a 19-nortestosterone derivative with two special structural changes [Fig. 1a]: [a] At the cabon-17 position there is a cyanomethyl group instead of an ethinyl group; [b] A double bond is present between carbons 9 and 10. DNG is the only progestogen that combines prope
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