• br Introduction Bone marrow adipocytes are one of

  2019-06-14

  

  Introduction Bone marrow adipocytes are one of the most abundant cell types found in bone marrow tissue. They constitute approximately 15% of the bone marrow volume in young adults, rising to 60% by the age of 65 years old [1]. Previously considered as inert space filling cells with little biolog

• br Conflict of interest br Introduction

  2019-06-14

  

  Conflict of interest Introduction Bladder cancer is one of the most common cancers in the world. It is estimated that around 74,000 new cases of p coumaric acid cancer and 16,000 bladder cancer-related deaths will occur in the United States in 2015. It is prominent in men and in the elderly po

• br Conclusion br Conflict of interest

  2019-06-14

  

  Conclusion Conflict of interest Introduction Dermatofibrosarcoma protuberans (DFSP) is a rare soft-tissue neoplasm that was first identified by Taylor, RW in 1890. It was then described in 1924 by Darier, J and Ferrand, M as a progressive recurrent dermatofibroma, and was later termed DFSP

• Nos anos de alguns setores da Igreja cat

  2019-06-14

  

  Nos anos de 1970 alguns setores da Igreja católica iniciaram uma nova etapa na ligação da instituição com as elites e a política. Outrora a Igreja era parte integrante desse arranjo, neste período se converteu em contestadora da acumulação financeira, das desigualdades, do latifúndio e da autoridade

• Na defini o da Secretaria

  2019-06-14

  

  Na definição da Secretaria Nacional de Políticas de Promoção da Igualdade Racial, vinculada atualmente ao Ministério dos Direitos Humanos do governo federal, as ações afirmativas são políticas públicas que têm como objetivo mct2 inhibitor correção de desigualdades raciais acumuladas ao longo dos ano

• br Hematopoietic cell transplantation HCT is generally recom

  2019-06-14

  

  Hematopoietic cell transplantation HCT is generally recommended for AML patients with intermediate or high risk cytogenetics, when the aim of treatment is curative. However, elderly patients are seldom offered a transplant mainly due to concerns regarding toxicity, despite the fact that the main

• 2-deoxy-d-glucose A Framework Convention on Global Health FC

  2019-06-13

  

  A Framework Convention on Global Health (FCGH)—supported by civil society and global leaders—should become the centrepiece of this endeavour (). It would reform global governance for health to enhance accountability, transparency, and civil society participation and protect the right to health in tr

• br As outlined in in October my vision for WHO

  2019-06-13

  

  As outlined in in October, 2016, my vision for WHO can be summed up in five words: equity, rights, responsiveness, evidence, and partnership. In this autophagy pathway context, I am pleased to respond to the authors of the open letter in , on the leadership role that WHO must play in tackling th

• Introduction The Space Shuttle has been retired and the Inte

  2019-06-13

  

  Introduction The Space Shuttle has been retired and the International Space Station (ISS) will be in use until 2020 (Fig. 1). Scientists and engineers are thinking about a mission to Mars in the future. Human exploration of space is at a turning point, and a number of questions about the future of

• br Discussion We evaluated and determined the incidence

  2019-06-13

  

  Discussion We evaluated and determined the incidence and severity of subjective reports of dyspepsia symptoms due to dabigatran. Based on the results of the RE-LY trial [4], the AE that was significantly more common with dabigatran than with warfarin was dyspepsia. In the sub-group (326 Japanese

• br Introduction Epidemiological studies have

  2019-06-13

  

  Introduction Epidemiological studies have shown that viral infections such as hepatitis C virus (HCV) and hepatitis B virus (HBV) are important factors contributing to hepatocellular carcinoma (HCC) development. Chronic HCV leads to cirrhosis in approximately 20% of patients over a 10–20 year per

• Introduction Paraneoplastic immune mediated encephalopathy i

  2019-06-13

  

  Introduction Paraneoplastic immune-mediated encephalopathy is a newly described disease. In 2005, Vitaliani et al first reported that four young women with ovarian teratoma (OT) had developed acute psychiatric and neurologic symptoms, e.g., seizures, memory deficits, decreased level of consciousnes

• In patients with ovary lesions surgical intervention play an

  2019-06-13

  

  In patients with ovary lesions, surgical intervention play an important role to establish correct diagnosis. First of all, obtaining histologic confirmation of disease by laparotomy is critical in differentiating primary ovarian cancer between metastatic lesions such as gastric cancer to the ovary (

• The pathophysiology underlying ONJ is unclear Decreased bone

  2019-06-13

  

  The pathophysiology underlying ONJ is unclear. Decreased bone remodeling induced by bisphosphonates or inhibition of osteoclast function, which interferes with healing of the microfractures and trauma occurring after dental extraction, have been hypothesized as potential mechanisms for ONJ, but thes

• In addition to CAF in the primary tumour

  2019-06-13

  

  In addition to CAF in the primary tumour microenvironment, it is tempting to speculate that fibroblasts within the bone itself may play a role in the establishment of metastatic deposits. Fibroblasts form a major component of the bone marrow stroma and regulate haematopoiesis by secreting a range of

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