• The second constraint indicates that if

  2019-07-25

  

  The second constraint indicates that if the relationship between two components A and B is two-way, then there are at least two connectors, one with origin A and destination B, and another connector with origin B and destination A (OCL2 of Fig. 4). Therefore, at least one output port of the first co

• Another interesting study was that by Kotyuk et

  2019-07-25

  

  Another interesting study was that by Kotyuk et al. (2015), who investigated the association between COMT rs4680 and personality in elderly people. The authors analysed the association between COMT rs4680 and NEO-FFI. The GG luciferin correlated with lower mean Neuroticism score and higher Agreeabl

• Introduction The COMT gene is located on

  2019-07-25

  

  Introduction The COMT gene is located on chromosomal band 22q11.2, extends over 28 kb, contains six exons, and encodes for catechol-O-methyl-transferase (Weinshilboum and Raymond, 1977; Grossman et al., 1992; Lundström et al., 1995; Bearden et al., 2005). This enzyme plays a major role in regulatio

• br Materials and methods br Results Recently a

  2019-07-25

  

  Materials and methods Results Recently, a quantitative proteomic analysis of C2C12 mouse myoblasts cell line totally deprived of protein kinase CK2 catalytic subunits (CK2α/CK2α′(−/−)), suggested that the cellular expression of HSP27, a chaperone with multiple functions related to proteostasis

• L-161,982 It is of interest to

  2019-07-25

  

  It is of interest to point out that curcumin in this study reduced body weight gain; the underlying mechanism may be due to a decrease in general L-161,982 of fat, which was associated with a significantly reduced NPC1L1 expression in small intestine. Labonte et al revealed that NPC1L1 deficiency o

• EPAC induces SOCS gene expression

  2019-07-25

  

  EPAC1 induces SOCS3 gene expression in VECs, resulting in suppression of the JAK–STAT activation initiated by the sIL-6Rα/IL-6 trans-signalling complex [67]. EPAC1 regulates SOCS3 gene induction through the activation of C/EBP and c-Jun transcription factors, which interact directly with the SOCS3 p

• Although PKC in cancer cells is known to promote

  2019-07-25

  

  Although PKCδ in cancer JWH 133 where is known to promote antiapoptotic signaling, a cleaved form of PKCδ, δCF, has been reported to play a contrasting role in enhancing apoptosis (Reyland, 2007), and these complex functions appear to be cell-type dependent (Basu and Pal, 2010). In NSCLC, full-leng

• Acidic substituents showed moderate biochemical

  2019-07-24

  

  Acidic substituents () showed moderate biochemical activity, but these compounds showed reduced cellular potency. Additional compounds bearing a carboxylic ci-1033 were also prepared and tested (data not shown). All of acidic compounds showed low cellular potency regardless of their biochemical act

• Based on the finding described above the present

  2019-07-24

  

  Based on the finding described above, the present study was designed to investigate the effects of specific CRF receptors, CRF1 and CRF2, in the BLA and CeA on the duration of TI in guinea pigs (Cavia porcellus). To this end, we evaluated whether administration of the CRF1 Concanamycin A antagonist

• Compounds and were outliers for this

  2019-07-24

  

  Compounds and were outliers for this equation being the two most reactive compounds. The presence of outliers implies that other factors or specific mechanisms are involved in their chemical hydrolysis. Generally urea derivatives prove to be highly stable in aqueous solutions in vitro. Additional

• Currently phosphodiesterase type PDE inhibitors are used wid

  2019-07-24

  

  Currently, phosphodiesterase type 5 (PDE-5) inhibitors are used widely as the first- line oral treatment for erectile dysfunction of varying causes. Radical prostatectomy for the treatment of prostate cancer is frequently associated with erectile dysfunction, and this type of erectile dysfunction is

• br Significance Our understanding of the ubiquitin biology h

  2019-07-24

  

  Significance Our understanding of the ubiquitin biology has been rapidly expanding. The role of the ubiquitin system in the pathogenesis of numerous disease states has increased the interest in finding new strategies to pharmacologically interfere with the enzymes responsible of the ubiquitinatio

• The underlying assumption of consolidation re

  2019-07-24

  

  The underlying assumption of consolidation/re-consolidation is that the NS 11394 solubility activity initiated during the acquisition trial/re-consolidation trial continues to persist briefly after completion of the trial and it is during this post-trial period that immediate post-trial treatments

• In this study we investigated the role

  2019-07-24

  

  In this study we investigated the role 17-phenyl tinor (pt)-PGE2 on endothelial barrier function and the underlying molecular mechanism in HMVEC-Ls as well as in a murine model of LPS-induced acute pulmonary inflammation. We found that 17-pt-PGE2 concentration-dependently enhanced endothelial barrie

• Recent studies from the literature have identified new class

  2019-07-24

  

  Recent studies from the literature have identified new prostaglandin synthase of antiviral agents able to target diverse host factors indispensable for efficient virus replication: as an example, the human DEAD-box polypeptide 3 (DDX3) inhibitor, 1-[4-(4-methyl-1H-1,2,3-triazol-1-yl)phenyl]-3-o-tol

13479 records 848/899 page Previous Next First page 上5页 846847848849850 下5页 Last page