• Introduction The Space Shuttle has been retired and the Inte

  2019-06-13

  

  Introduction The Space Shuttle has been retired and the International Space Station (ISS) will be in use until 2020 (Fig. 1). Scientists and engineers are thinking about a mission to Mars in the future. Human exploration of space is at a turning point, and a number of questions about the future of

• br Discussion We evaluated and determined the incidence

  2019-06-13

  

  Discussion We evaluated and determined the incidence and severity of subjective reports of dyspepsia symptoms due to dabigatran. Based on the results of the RE-LY trial [4], the AE that was significantly more common with dabigatran than with warfarin was dyspepsia. In the sub-group (326 Japanese

• br Introduction Epidemiological studies have

  2019-06-13

  

  Introduction Epidemiological studies have shown that viral infections such as hepatitis C virus (HCV) and hepatitis B virus (HBV) are important factors contributing to hepatocellular carcinoma (HCC) development. Chronic HCV leads to cirrhosis in approximately 20% of patients over a 10–20 year per

• Introduction Paraneoplastic immune mediated encephalopathy i

  2019-06-13

  

  Introduction Paraneoplastic immune-mediated encephalopathy is a newly described disease. In 2005, Vitaliani et al first reported that four young women with ovarian teratoma (OT) had developed acute psychiatric and neurologic symptoms, e.g., seizures, memory deficits, decreased level of consciousnes

• In patients with ovary lesions surgical intervention play an

  2019-06-13

  

  In patients with ovary lesions, surgical intervention play an important role to establish correct diagnosis. First of all, obtaining histologic confirmation of disease by laparotomy is critical in differentiating primary ovarian cancer between metastatic lesions such as gastric cancer to the ovary (

• The pathophysiology underlying ONJ is unclear Decreased bone

  2019-06-13

  

  The pathophysiology underlying ONJ is unclear. Decreased bone remodeling induced by bisphosphonates or inhibition of osteoclast function, which interferes with healing of the microfractures and trauma occurring after dental extraction, have been hypothesized as potential mechanisms for ONJ, but thes

• In addition to CAF in the primary tumour

  2019-06-13

  

  In addition to CAF in the primary tumour microenvironment, it is tempting to speculate that fibroblasts within the bone itself may play a role in the establishment of metastatic deposits. Fibroblasts form a major component of the bone marrow stroma and regulate haematopoiesis by secreting a range of

• El sujeto de la enunciaci n

  2019-06-13

  

  El sujeto de la enunciación se subordina thymidylate synthase la autoridad y dominio del príncipe y, por interpósita persona del rey, como súbdito y leal servidor: “[…] tuve por conveniente servir a vuestra alteza con este sumario brevísimo de muy difusa hystoria que de los estragos e perdiciones ac

• Con frecuencia el tratamiento de la fauna en Indias

  2019-06-13

  

  Con frecuencia el tratamiento de la raas inhibitors en Indias no es muy diferente; el bestiario que pudiera emerger de las crónicas abarca una fauna en la que la mirada acentúa lo diferente y lo exótico, el mito y la leyenda, pero ante todo se expresa y plasma en una estética en la que van juntos e

• Findings Baseline data were collected between Sept and Nov B

  2019-06-13

  

  Findings Baseline data were collected between Sept 6, 2011, and Nov 11, 2012. Between January, 2013, and September, 2014, 62 midwives completed triage training and we collected post-training triage data from Dec 12, 2014, to January 24, 2015. In 2014, compliance of use and correctness of wristbandi

• The exhibited efficacies of bone targeting treatments in pha

  2019-06-12

  

  The exhibited efficacies of bone targeting treatments, in phase III clinical trials, suggest significant progress in delaying skeletal-related events, with improvements having been seen in the direct comparisons between generations of drugs. These findings also lend clear support to the utility of b

• br A KCNJ mutation corresponding to an S L mutation

  2019-06-12

  

  A KCNJ8 mutation, corresponding to an S422L mutation in the protein, was first identified in a 14-year-old girl with early repolarization [59], who suffered frequent VF attacks. KCNJ8 encodes Kir6.1, which has 2 transmembrane regions, and the KATP channel is composed of a complex of Kir6.1 or Kir6

• Durrer et al reported that ventricular depolarization begins

  2019-06-12

  

  Durrer et al. [17] reported that ventricular depolarization begins in the LV septum, which suggests that initiating pacing from regions close to this area (e.g., RV septum) may produce a physiologic contraction pattern. In contrast, the free wall of the RV is the last zone to be depolarized. Thus, i

• We are aware that physician surveys have been previously use

  2019-06-12

  

  We are aware that physician surveys have been previously used to assess; bisphosphonate use for bone pain [14], bisphosphonate use in metastatic breast cancer patients [15] and radiotherapy use for painful bone metastases [16] but are not aware of physician surveys being used to help design trials o

• In the normal BMD subgroup there was

  2019-06-12

  

  In the normal BMD subgroup, there was progressive bone loss over 3 years at the spine and hip (5.4% and 4.5%, respectively). This finding is consistent with the ATAC data [5]. Two patients required alendronate triggered by clinical events but there were no algorithm triggered events. There were no n

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