• The combination therapy was exceedingly

  2019-04-28

  

  The combination therapy was exceedingly well tolerated without any side effects to either drug. Remarkably, despite an advanced PV-stage the JAK2V617F allele burden was rapidly lowered from 90% mutated PR619 at referral to 59% at 6 months, 28% at 10 months and 12% at 16 months of therapy (Fig. 2).

• Introduction Acute acalculous cholecystitis ACC is defined a

  2019-04-28

  

  Introduction Acute acalculous cholecystitis (ACC) is defined as an acute necroinflammatory disease of the gallbladder in the absence of cholelithiasis and has a multifactorial pathogenesis [1]. ACC has very rarely been described in patients undergoing myelosuppressive chemotherapy for acute myelobl

• This is the first report

  2019-04-28

  

  This is the first report describing the occurrence of HLH in a patient with refractory CLL who had started Ibrutinib treatment. Hemophagocytic lymphohistiocytosis (HLH) is a rare and frequently fatal disorder characterized by an ineffective T-cell and NK response resulting in an exuberant cytokine p

• Gender transformative policy and cultural reforms are also

  2019-04-26

  

  Gender transformative policy and cultural reforms are also crucial to change prevailing norms and customs that devalue women and girls. Implementation and enforcement of non-discriminatory policies and practices that require gender equity in inheritance, property rights, education, and civil liberti

• El caso argentino sobre la literatura fant

  2019-04-26

  

  El caso argentino sobre la literatura fantástica puede ser interpretado de modo similar al de Mukarovsky, niclosamide propósito de la obra de arte como hecho semiológico (estético/social): por un lado, se encuentra el signo poético, que Macedonio y Borges recuperan en la obra literaria mediante sus

• gadobutrol El ltimo espacio que Idalia visit fue

  2019-04-26

  

  El último espacio que Idalia visitó fue la sala de exposiciones del Centro Cultural Universitario Tlatelolco de la unam en 2012. La exposición “Pedro Valtierra. Mirada y testimonio”, permitió que este ícono de la obra de Valtierra adquiriera otro significado. A partir de esta retrospectiva se obtuvo

• Three possible mechanisms may underlie

  2019-04-26

  

  Three possible mechanisms may underlie the decrease in the number of PVBs in the present patient: the first is the antiarrhythmic action of Omacor, the second is the natural time course of PVBs, and the third is the day-to-day variability in the number of PVBs. Therefore, we performed an additional

• However the patient was later re admitted with frequent palp

  2019-04-26

  

  However, the patient was later re-admitted with frequent palpitation symptoms similar to those exhibited prior to the initial RFCA. Despite oral class I antiarrhythmic drug and beta-blocker treatment, ECG revealed incessant ATs and symptomatic AF (Fig. 2), so repeat RFCA was performed. Intravenous b

• Despite our best efforts the

  2019-04-26

  

  Despite our best efforts, the cause of SCD in young individuals is sometimes not established; no cause is identified in up to 40% of cases. Importantly, whether a cause of death is established or not, the possibility of an underlying inherited cardiac disorder remains in many cases, including the po

• Second the intervention was delivered

  2019-04-25

  

  Second, the intervention was delivered by olda volunteers and administered through a local non-governmental organisation (NGO) that was committed to ongoing community involvement. Intervention success is dependent on quality. In this Ugandan trial, quality was enhanced by the reputation, maturity,

• Eosinophilia often occurs as a secondary

  2019-04-25

  

  Eosinophilia often occurs as a secondary process due to parasitic infections, allergy, Anti-infection Compound Library disease, malignancy, or drug reactions. When secondary causes of eosinophilia are excluded, one must consider HES, which is defined as a peripheral eosinophil count of greater than

• Given this proud history it is deeply

  2019-04-25

  

  Given this proud history, it TAK-875 is deeply concerning that newly elected President Donald J Trump, has, through an executive order in his fourth day in office, reinstated a Reagan-era prohibition on the disbursement of federal funding to non-governmental organisations (NGOs) and agencies that p

• Then we try to provide evidence to show that the

  2019-04-25

  

  Then, we try to provide evidence to show that the mechanism of GLT-1 down-regulation after lethal OGD may be related to the activation of p38 MAPK in astrocyte-neuron co-cultures. Firstly, it was observed that p-p38 MAPK expression in astrocytes was significantly increased after lethal OGD by wester

• Introduction Atrial fibrillation AF is a highly

  2019-04-25

  

  Introduction Atrial fibrillation (AF) is a highly prevalent atrial arrhythmia that affects approximately 10% of individuals older than 75 years of age and tends to increase in prevalence with advancing age [1–3]. Although AF itself is not life threatening, it is a risk factor for stroke, and the AF

• Introduction Neuroblastoma NB which arises from embryonal ne

  2019-04-25

  

  Introduction Neuroblastoma (NB), which arises from embryonal neural crest cells, is the most common extra-cranial solid tumor of childhood and accounts for more than 15% of all child cancer death [1,2]. Patients with NB frequently manifest disseminated disease at first visit and prognosis of these

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