• VX-765 in Cell Death Mechanisms: Caspase-1 Inhibition and...

  2025-09-22

  Explore how VX-765, a selective caspase-1 inhibitor, advances understanding of inflammatory cytokine modulation and pyroptosis inhibition in macrophages. This article integrates new perspectives on VX-765's utility in dissecting cell death pathways relevant to inflammation and transcriptional stress.

• RSL3 and Ferroptosis: Targeting GPX4 for Cancer Research ...

  2025-09-19

  Explore the mechanistic role of RSL3, a potent GPX4 inhibitor for ferroptosis induction, in elucidating oxidative stress pathways and iron-dependent cell death in cancer research. This article provides a rigorous analysis of RSL3's applications and contrasts ferroptosis with recent advances in apoptotic cell death signaling.

• SM-164: Mechanistic Insights into Bivalent Smac Mimetics ...

  2025-09-18

  Explore the mechanistic basis of SM-164, a bivalent Smac mimetic and potent IAP antagonist for cancer therapy, focusing on its role in apoptosis induction in tumor cells. This article reviews recent advances in IAP-mediated apoptosis inhibition, placing SM-164 in the context of emerging apoptotic signaling pathways.

• An important observation is that this

  2025-03-03

  

  An important observation is that this patient has been on ALK inhibitor for more than 4 years (51 months: 27 months on crizotinib+24 months on alectinib and on-going) and there was no evidence of disease progression in the central nervous system. The other potential driver mutation in this patient’s

• br Concluding remarks Following the disappointing

  2025-03-03

  

  Concluding remarks Following the disappointing outcomes of Aβ immunotherapy trials for AD [62], the current prevailing concept is that disease-modifying therapy must be initiated from the presymptomatic stage of the disease because of the presumed incurability of chronic diseases once they become

• A combination of factors might however

  2025-03-03

  

  A combination of factors might, however, account for the low rate of success of drug development for neuropsychiatric disorders. First, in most neuropsychiatric disorders, the symptomatology is heterogeneous and the neurobiology remains poorly understood, making therapeutic targets difficult to iden

• br Dihydrotestosterone in adult fish and

  2025-03-03

  

  Dihydrotestosterone in adult fish and frogs New perspectives and next directions Similar to other androgens, DHT can modulate reproductive endpoints in both fish and amphibians. However, predicting the effects of DHT can be challenging, as reproductive homeostasis is dependent upon the balance

• br Acknowledgements br Introduction Thus damage to

  2025-03-03

  

  Acknowledgements Introduction Thus, damage to the Vacquinol-1 may produce severe consequences (National Research Council, 1992). Indeed, though the nervous system has several compensatory and adaptive mechanisms, it is vulnerable to toxic insult, due to its inability to regenerate after letha

• Another topic for research will be the

  2025-03-03

  

  Another topic for research will be the combination of other cytotoxic agents with Aurora kinase inhibitors. Particularly interesting might be the combination of Aurora kinase inhibitors and agents that depend on the spindle checkpoint for their activity, such as the taxanes, given the importance of

• Furthermore because most of foods and beverages have been co

  2025-03-01

  

  Furthermore, because most of foods and beverages have been consumed after processing, researchers have focused on the effects of processing (e.g. blanching, cooking, drying, cooling, freezing, high-pressure treatment, pulsed electric field) on total antioxidant capacity of foods. In general, there w

• Although the interactions of PhLP with G and

  2025-03-01

  

  Although the interactions of PhLP with Gβγ and its other partners have been convincingly documented through in vitro studies, it is not clear how PhLP controls LY2801653 signaling in vivo. C. elegans provides a powerful genetic model to analyze Phosducin function and study its interacting partners

• br Results A total of respondents

  2025-03-01

  

  Results A total of 126 respondents completed the survey (68.5% response rate), with at least 65% response rate from each of the four represented sectors (denominators represent the total constituent body of the organization or the total attendees of the meeting): PUC 24 out of 37 (65%), SPUNZA 33

• br Acknowledgement Work in the McEwan Laboratory is funded b

  2025-03-01

  

  Acknowledgement Work in the McEwan Laboratory is funded by the Chief Scientist Office of Scottish Government: Grants ETM-258 and ETM-382. BE is supported by an Erasmus scholarship (D -JENA01). Introduction The equine placenta is a noninvasive transient organ, classified as diffuse and epithel

• Women are usually at risk of sleep deprivation or

  2025-03-01

  

  Women are usually at risk of sleep deprivation or restriction during pregnancy, especially in the third trimester of gestation, due to the pregnancy-associated anatomic, physiological and hormonal changes (Pien and Schwab, 2004). However, several major Moxidectin developmental events, such as the ne

• br Concluding remarks The past decade has seen

  2025-03-01

  

  Concluding remarks The past decade has seen rapid advances in our understanding of the metabolic reprogramming that occurs during tumorigenesis. Strategies to target specific nodes of cancer cell amino perifosine metabolism have progressed from preclinical studies to clinical trials, and are show

13449 records 1/897 page Next 12345 下5页 Last page